Blood work and biomarker testing provide valuable insights into lifespan and disease risk, particularly for atherosclerotic disease, cancer, neurodegenerative disease, and metabolic disease. Functional testing is important for assessing cognitive and emotional health. DEXA scans are recommended for measuring lean mass, bone mineral density, and assessing osteoporosis risk. Strength training, especially powerlifting, improves bone mineral density and is crucial for bone development in females. Hormone replacement therapy (HRT) should be tailored to individual needs, with estrogen being generally effective and testosterone therapy requiring more research. Exercise is crucial for brain health, longevity, and vitality, and can reduce the risk of Alzheimer's disease. Nicotine can enhance cognitive function but should be used with caution. Menopause and menstruation can be managed through HRT, and hormone levels should be monitored. Cholesterol levels and ApoB are important markers for cardiovascular disease risk. Peptides, stem cells, and PRP injections for injury rehabilitation require further research. Metabolomics explores the effects of exercise on the body and has potential for future treatments. GLP-1 agonists show promise for weight loss but should be used in conjunction with behavioral changes. Supporting the Huberman Lab Podcast can be done through subscribing, leaving reviews, checking out sponsors, and following on social media.
Assessing Health Status & Improving Vitality
Assessing Health Status & Improving Vitality
- Dr. Peter Attia discusses interventions to optimize vitality and extend longevity
- Topics covered include evaluating health status, defining health trajectory, and importance of blood work
- Expertise spans exercise physiology, sleep physiology, mental health, and pharmacology
- Covers blood work results that may be counterintuitive but impact lifespan and health span
- Topics include hormone health, therapies for men and women, drug therapies, supplementation, nutrition, exercise, and predictors of lifespan and health span
- Valuable information provided, listeners can take notes or refer to timestamped topics of interest.
Lifespan: Bloodwork & Biomarkers Testing, The “4 Horseman of Disease”
The most profound aspect of blood work and biomarkers testing is its ability to provide valuable insights into lifespan and the risk of diseases.
Key points:
- Blood work is important for optimizing health and performance, especially for athletes.
- Blood work has limitations and blind spots when it comes to assessing overall vitality.
- Lifespan and health span are two vectors of longevity, with lifespan being a binary measure of being alive or not.
- The four horsemen of disease that impact lifespan are atherosclerotic disease, cancer, neurodegenerative disease, and metabolic disease.
- Bloodwork can help predict the risk of atherosclerosis through markers of inflammation, endothelial health, and metabolic health.
- Blood testing is not particularly helpful for cancer, as it is largely driven by bad luck, although metabolic ill health plays a role.
- Biomarkers can be useful for understanding dementia, particularly Alzheimer's disease, as they overlap with atherosclerotic diseases.
- Genetic testing can provide novel insights into lifespan and disease risk.
Healthspan: Functional Testing, Cognitive & Emotional States
The most profound aspect of the topic is the importance of functional testing for healthspan, cognitive, and emotional states.
Key points:
- Biomarkers are useful for assessing physical health but less useful for cognitive and emotional health.
- Cognitive testing and reducing the risk of dementia are important for cognitive health.
- Functional tests such as DEXA, CPET, VO2 max, and fat oxidation provide insight into physical health.
- Emotional health is considered the most important aspect of overall well-being.
- Focusing on optimizing physical health without considering emotional health is ironic.
Blood Testing: Best Frequency
Blood testing frequency depends on the need for monitoring changes and the state of interventions. It is important to screen individuals early in life to identify genetic drivers of conditions like atherosclerosis. Testing should be done when there is a reason to assess a specific level or monitor the effects of interventions. In clinical practice, blood tests are typically done two to four times a year, considering desired outcomes and potential changes in health markers.
DEXA Scan: Lean Mass & Fat, Bone Mineral Density & Osteoporosis
A DEXA scan is a recommended method for measuring lean mass percentages and obtaining four pieces of information about the body. It is considered more accurate than weight or BMI measurements. DEXA scans use x-ray technology to pass ionizing radiation through the body and collect data on the density of different tissues.
Key points:
- DEXA scans are more accurate than weight or BMI measurements for assessing body composition.
- DEXA scans use x-ray technology to measure the density of different tissues in the body.
- DEXA scans provide important metrics for assessing health, including bone mineral density, visceral fat, appendicular lean mass index, and fat-free mass index.
- Bone mineral density is crucial for women approaching or experiencing menopause, as low density increases the risk of osteopenia and osteoporosis.
- DEXA scans provide Z-scores to compare an individual's metrics to age-related charts, allowing for targeted strategies to improve or prevent further decline.
- The goal is to maintain or improve Z-scores over time to maintain bone density.
Bone Mineral Density & Age-Related Decline, Strength Training, Corticosteroids
Strength training, particularly powerlifting, is the best exercise for improving bone mineral density, especially during the critical window of development before the age of 20 or 25. Bones respond to the sheer force applied through the muscles and tendons, activating osteoblasts and allowing bone to be built. This is particularly important for females, as their bone development during this period sets the trajectory for the rest of their lives. Patients who have used corticosteroids during this critical window may have impaired bone development, posing a significant challenge that requires interventions such as nutrition, hormones, drugs, and training.
Key points:
- Strength training, specifically powerlifting, is the most effective exercise for improving bone mineral density.
- Bone development before the age of 20 or 25 is crucial, especially for females.
- Corticosteroid use during this critical window can impair bone development.
- Interventions such as nutrition, hormones, drugs, and training are necessary to address impaired bone development.
- Inhalants and topical corticosteroids can have a negative impact on bone mineral density.
- Strength training is recommended for individuals taking corticosteroids to counteract the negative effects on bone health.
- Strength training is beneficial for bone health throughout life, even for individuals in their 30s, 40s, or 50s.
- Low repetition ranges, heavy loads, and long rest periods are recommended for strength training to prevent age-related decline in bone mineral density.
- Strength training can improve bone health in older individuals with osteopenia or osteoporosis.
- It's never too late to start strength training and it should be a lifelong practice to maintain bone health.
Osteopenia & Osteoporosis Diagnosis, Strength Training
Strength training has both local and systemic effects on bone density. The diagnosis of osteopenia and osteoporosis is based on specific locations in the body, but bone density outside of these regions also matters. The majority of the response to strength training is local, as it stimulates bone growth in the loaded area.
Back-casting: Defining Your “Marginal Decade”
The concept of back-casting and defining one's "marginal decade" is discussed in the video. Back-casting involves planning and setting goals by working backwards from a desired outcome. The speaker emphasizes the importance of knowing what one wants to achieve in their final years in order to design a program to reach that goal. This process is referred to as back-casting. The speaker suggests that everyone should go through this exercise, regardless of age, to determine what they want their last decade to look like and then work backwards to figure out what actions they should take based on their current health status.
All-Cause Mortality: Smoking, Strength, VO2 max
The impact of smoking on all-cause mortality:
- Smoking, whether nicotine or cannabis, significantly decreases lifespan
- Smoking increases the risk of all-cause mortality by approximately 40%
Factors contributing to all-cause mortality:
- High blood pressure is associated with a 20-25% increase in all-cause mortality
- End-stage kidney disease leads to a significant 175% increase in all-cause mortality
- Low muscle mass is linked to a three-fold increase in all-cause mortality, primarily due to low strength
- Low strength is associated with a 250% greater risk of death compared to high strength
The relationship between strength, VO2 max, and all-cause mortality:
- Strength is measured using metrics such as grip strength, leg extensions, and wall sits
- VO2 max has a profound impact on all-cause mortality
- Individuals in the bottom 25% for their age and sex have a two-fold increased risk compared to those in the 50th to 75th percentile
- Comparing the bottom 25% to the top 2.5% (elite), there is a five-fold difference in all-cause mortality
- VO2 max reflects an individual's fitness level, not necessarily tied to running marathons
Maintaining a high level of VO2 max is important for longevity and vitality, even without being a world-class athlete.
Attia’s Rule of Supplementation, “Centenarian Decathlete” Physical Goals
Dr. Peter Attia emphasizes the importance of prioritizing exercise before discussing supplements or nutrition. He suggests specific physical goals such as deadlifting body weight for 10 reps, reaching a certain VO2 max percentile, and performing exercises like dead hangs and wall sits. Attia's rule states that individuals should refrain from discussing supplements until achieving these benchmarks.
- Physical goals for vitality and longevity: dead hang for 1-2 minutes, specific VO2 max percentiles, farmer carries.
- Attia's Rule of Supplementation: prioritize exercise before discussing supplements or nutrition.
- Introduction of the "centenarian decathlete" test to assess physical capabilities.
- Discussion of exercise-related neurogenesis in mice, not directly related to the main topic.
Importance of Exercise, Brain Health, MET hours
Exercise is crucial for brain health and longevity. Studies have shown that lack of movement and sensory deprivation can lead to neuronal atrophy and loss of connections, while physical activity can enhance neuronal size and connections. Exercise is the most effective intervention for brain health, impacting BDNF levels, vascular health, glucose disposal, and insulin signaling. Going from being sedentary to doing 15 MET hours of exercise per week can reduce the risk of Alzheimer's by 50%. Just three one-hour brisk walks per week can provide significant benefits. Exercise also contributes to overall health span. Nobel prize winners in their 90s are still mentally sharp and active because they engage in regular exercise activities. MET hours are a useful metric for understanding the benefits of exercise.
Nicotine & Cognitive Focus
Nicotine, specifically the augmentation of nicotinic acetylcholine receptors, has been found to enhance focus and cognitive function. However, smoking or vaping nicotine is detrimental to health and should be avoided. The use of nicotine for cognitive enhancement is a personal choice, and some individuals have been using nicotine in the form of gum or lozenges for this purpose. While there is limited evidence on the prevention of Alzheimer's disease, nicotine's cognitive enhancement effects have been discussed extensively.
Key points:
- Nicotine enhances focus and cognitive function by augmenting nicotinic acetylcholine receptors.
- Smoking or vaping nicotine is harmful to health and should be avoided.
- Some individuals use nicotine in the form of gum or lozenges for cognitive enhancement.
- Limited evidence on the prevention of Alzheimer's disease with nicotine.
- Nicotine is a concentration-enhancing substance, but high doses can be harmful.
- Nicotine is considered safer than stimulants for improving focus.
- Medical professionals do not typically prescribe stimulants for cognitive enhancement.
- Changing one's environment is likely to have a greater impact on focus than substances like nicotine.
- Nicotine can improve attention and focus, but this is based on anecdotal evidence and not clinical trials.
Menstruation, PMS & Menopause
Menopause and Hormone Therapy:
- Timing of estrogen therapy during menopause is crucial
- Initiating therapy in the middle to tail end of menopause can have negative outcomes
- Starting therapy before or during menopause can have positive outcomes
- Criticism of the medical field's handling of hormone replacement therapy for women
- Women's Health Initiative study turned the medical field off hormone replacement therapy for women
Menstruation and Hormone Fluctuations:
- Fluctuation of hormone levels during the menstrual cycle
- Estrogen is the dominant hormone, but women have more testosterone in their bodies
- Rise in estrogen levels in response to follicle stimulating hormone (FSH) prepares the body for ovulation
- Ovulation typically occurs at the midpoint of the cycle
- Progesterone dominates the second half of the cycle
- Rapid reduction of progesterone during menstruation can cause PMS symptoms
PMS and Menstruation:
- Stabilizing progesterone levels during the luteal phase can alleviate PMS symptoms
- Progesterone receptors in the brain may be linked to emotions
- Menstruation starts when estrogen and progesterone reach their lowest levels
- Eventually, women will stop menstruating as their estrogen levels decrease.
Hormone Replacement Therapy, Menopause & Breast Cancer Risk
Hormone Replacement Therapy (HRT) is a treatment for menopause symptoms in women. It initially used estrogen, but the addition of progesterone was necessary to counter the increased risk of uterine cancer. The Women's Health Initiative (WHI) study analyzed the effects of HRT on women's health, but its design and participant selection were considered unusual. Another study discussed the limitations of HRT, including the use of outdated hormones and a disproportionately unhealthy patient population. HRT has been associated with a small increase in breast cancer risk, but the absolute risk increase is minimal. The benefits of HRT, such as using bio-identical hormones, should be considered along with the potential risks. Synthetic progesterone (MPA) has shown both an increase and a reduction in breast cancer risk, while oral estrogen increases blood clotting. Topical forms of HRT are preferred to reduce the risk of heart disease.
Estrogen, Progesterone & Testosterone Therapies in Women
The most profound aspect of the text is the importance of working with a gynecologist for hormone replacement therapy (HRT) in women, including regular ultrasounds and pap smears.
Key points:
- Estrogen is generally effective in addressing most issues in HRT.
- Tolerance for progesterone varies among women, with some experiencing benefits like improved sleep and thicker hair, while others may have negative effects.
- For women with negative effects from progesterone, a progesterone-coated IUD is recommended for local protection in the uterus, along with systemic estrogen.
- The long-term effects of chronic estrogen use through oral contraception are not a significant concern in the speaker's patient population.
- Low synthetic estrogen is sometimes used as a treatment for certain symptoms, although it is not commonly used.
- Testosterone levels are higher than estrogen in women when normalized, but caution is advised in prescribing testosterone therapy due to a lack of data.
- More research and trials are needed to determine the appropriate use of testosterone in women.
- Topical testosterone can be used in women to replace hormone levels to a physiologically normal range without causing symptoms like acne or body hair.
- Clitoral enlargement does not occur under normal physiological conditions.
- The video briefly mentions hormone replacement therapy in men.
Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin
Hormone Replacement Therapy in Men, SHBG & Testosterone, Insulin:
- Hormone replacement therapy in men involves looking at various hormones, including estrogen and DHT, and understanding the ranges for testosterone levels.
- Anavar can be used to lower SHBG and increase free testosterone levels, but it is not recommended due to potential consequences.
- Three hormones play a role in SHBG: estradiol, insulin, and thyroxine.
- Insulin suppresses SHBG, so lowering insulin levels can decrease free testosterone.
- A low carbohydrate diet can increase SHBG by lowering insulin levels.
- Higher estradiol levels also increase SHBG.
- Aromatase inhibitors can lower estradiol and subsequently decrease SHBG.
- Thyroid imbalances can interfere with SHBG and need to be addressed.
- There are supplements that can affect SHBG levels, but no known supplement can significantly lower SHBG levels.
- Free testosterone is important, and if it is low, total testosterone levels may need to be increased.
- Anavarax is no longer used to lower SHBG due to complexity and potential complications.
- Hormone replacement therapy can improve symptoms and biomarkers, including glycemic control and insulin signaling.
- HRT can be achieved through exercise and other methods, with Clomid being a commonly used option.
Clomid, Pituitary, Testosterone & Cholesterol, Anastrozole, HCG
The use of medications such as anastrozole, Clomid, and testosterone to regulate hormone levels in the body is discussed. Some negative side effects of anastrozole are mentioned, as well as the potential fat accumulation from low estrogen levels. A study on the effects of testosterone and anastrozole on chemically castrated men is discussed, showing that higher testosterone levels and moderate estradiol levels are associated with better outcomes. Clomid is mentioned as a medication that can stimulate testosterone production. Synthetic compounds like Clomid, testosterone, estrogen, and anastrozole are used to treat hormonal deficiencies. Proper dosing in testosterone replacement therapy (TRT) is emphasized, with lower, more frequent doses of testosterone and limited use of aromatase inhibitors recommended. Clomid is found to increase levels of desmosterol, a sterol important in measuring cholesterol synthesis and reabsorption. The use of Clomid is being replaced with HCG due to concerns about desmosterol's potential damage. Clomid and HCG are both used to preserve testicular function and volume, with Clomid commonly used in post-cycle therapy by bodybuilders and HCG acting as an analog of luteinizing hormone.
Fadogia Agrestis, Supplements, Rapamycin
The supplement Fadogia agrestis has the potential to increase luteinizing hormone and affect testicular size and volume, but its long-term safety and efficacy are not well-known. Regulation and sourcing in the supplement industry are important considerations. Fadogia agrestis is seen as a middle ground between no supplementation and hormone therapy.
Key points:
- Fadogia agrestis can increase luteinizing hormone and impact testicular size and volume
- Limited information on the long-term safety and efficacy of Fadogia agrestis
- Regulation and sourcing are important in the supplement industry
- Fadogia agrestis is considered an intermediate step between no supplementation and hormone therapy.
Many people take supplements without fully understanding their purpose, so it is important to critically evaluate the reasons for taking each supplement. Measures like red light therapies and collagen supplements are used to increase testosterone levels and promote longevity and fertility.
Key points:
- Importance of critically evaluating reasons for taking supplements
- Various measures to increase testosterone levels and promote longevity and fertility
- Red light therapies and collagen supplements are mentioned
Rapamycin has been shown to preserve ovarian health in animal models, and there is hope for clinical trials to test its effects on women. Female fertility is a topic of interest for many people.
Key points:
- Rapamycin can preserve ovarian life in animal models
- Hope for clinical trials to test its effects on women
- Female fertility is of interest to many people.
Testosterone Replacement Therapy & Fertility
Testosterone Replacement Therapy (TRT) and Fertility:
- TRT can be managed through injections, with Sub-Q injections being the preferred method.
- HCG is used to maintain fertility and testicular size, but TRT is not recommended for men who want to maintain fertility.
- Benefits of appropriate TRT include improved feelings and abilities.
- Cautionary notes include monitoring markers such as LDL, blood pressure, water retention, and acne.
- TRT is typically administered in low doses, with bodybuilders taking much higher doses during high growth phases.
- Consideration of other factors and delaying TRT is important, especially for fertility reasons.
- HCG and Clomid can be used in TRT to preserve testicular function and kick-start pituitary function if needed.
- Different cycling protocols for TRT, such as alternating between testosterone and HCG, can be used.
- The distinction between total testosterone and free testosterone is important in understanding TRT.
- A potential development of a molecule to target SHBG and adjust free testosterone levels is discussed.
Total Testosterone vs. Free Testosterone
The difference between total testosterone and free testosterone is discussed in the video. The speaker emphasizes that absolute testosterone levels do not necessarily correlate with physical appearance. Factors such as free testosterone, estrogen, training, and nutrition also play a role. Fixing testosterone levels can improve recovery and muscle protein synthesis, but it is not the sole determinant of physical performance. The speaker's personal experience highlights the importance of other lifestyle factors in achieving optimal physique and performance. Taking testosterone alone does not have a significant impact, but it can enhance the ability to do more work and experience the psychological effect of effort. The conversation briefly touches on the cholesterol pathway and its relationship to testosterone.
Cholesterol & Dietary Cholesterol, Saturated Fat, LDL & HDL, Apolipoprotein B
The debate surrounding dietary cholesterol's impact on serum cholesterol, LDL, and HDL levels is ongoing. Some argue that consuming excessive saturated fat can increase LDL and decrease HDL levels. Others believe that any increase in saturated fat intake is detrimental, as the body already produces enough cholesterol for hormone production. When interpreting cholesterol charts, it is important to note that LDL and HDL levels are considered healthy ranges. While some individuals avoid saturated fats, others enjoy them in moderation and feel fine. There is a small group of people who consume high levels of cholesterol-rich foods and believe that extremely high LDL levels do not affect health. Cholesterol is a complex molecule that is synthesized by every cell in the body and is crucial for survival.
- Dietary cholesterol does not significantly contribute to the cholesterol levels in our body because it is esterified and mostly gets taken back to the liver for digestion.
- Cholesterol is essential for various bodily functions, including cell membranes and hormone production. It is also necessary for the digestion of food as it makes up bile salts.
- Our own cholesterol is recirculated in the body through a transporter called Niemann-pick C1-like 1. The body regulates the amount of cholesterol in circulation, either allowing it to enter the body or excreting it through feces.
- Dietary cholesterol, which is esterified, cannot pass through the transporter easily. Only a small fraction of dietary cholesterol is de-esterified and enters circulation, representing a small portion of the total body's cholesterol pool.
- Saturated fat consumption can raise LDL cholesterol, while cholesterol itself is a complex ring structure. LDL cholesterol is often misunderstood and is necessary for transporting cholesterol between cells.
- Cholesterol is transported in our blood through lipoproteins, which are spherical molecules containing cholesterol and triglycerides. Lipoproteins exist in different densities, with high density lipoprotein (HDL) being the highest and very low density lipoprotein (VLDL) being the lowest.
- Apolipoprotein B (ApoB) is a type of LDL that is considered a "bad actor" in about 10 to 20% of the population. It is the causative agent of atherosclerosis, which is a concern for longevity and vitality.
- Maintaining ApoB levels similar to those at birth is crucial for preventing atherosclerosis.
Apolipoprotein B, Diet, Statins & Other Cholesterol Prescriptions
Apolipoprotein B (ApoB), Diet, Statins & Other Cholesterol Prescriptions
- ApoB is a measure of LDL and VLDL particles carrying cholesterol and triglycerides.
- Restricting carbohydrate intake can lower ApoB, but increasing fat intake can still raise it.
- Dietary intervention alone is unlikely to achieve optimal ApoB levels.
- Statins inhibit cholesterol synthesis and increase LDL receptors to lower LDL levels.
- Statins have a benign side effect profile, with only 5% experiencing muscle soreness.
- Ezetimibe blocks cholesterol absorption and its effectiveness can be measured by phytosterols.
- Bempedoic acid blocks cholesterol synthesis in the liver with fewer side effects than statins.
- PCSK9 inhibitors are the most potent drugs for lowering cholesterol.
- Familial hypercholesterolemia is characterized by high cholesterol levels and hyperfunctioning PCSK9.
- Antibodies mimicking hypofunctioning PCSK9 are highly effective in reducing LDL cholesterol.
- Approximately 80% of patients over 45 are prescribed statins to reduce cardiovascular disease risk.
- ApoB is a marker for atherosclerosis, a major contributor to heart disease.
- Lack of awareness about ApoB's significance in preventing heart disease is a concern.
- Social media may contribute to the lack of discussion on ApoB and its importance.
Cardiovascular Disease, Age & Disease Risk
Cardiovascular Disease, Age & Disease Risk:
- Age is the biggest driver of risk for cardiovascular disease.
- A 70-year-old has a much higher risk compared to an unhealthy 30-year-old.
- Medicine 2.0 focuses on modifying 10-year risk and treating when the risk reaches a certain threshold.
- Medicine 3.0 emphasizes treating the causative agent of the disease.
- Identifying risk factors for diseases at an early age is important.
- Prevention is crucial in reducing the risk of diseases like glaucoma.
- Simplifying complex problems is beneficial, even if economic considerations are not addressed.
Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), Injury Rehabilitation
Peptides, Stem Cells, BPC157, PRP (Platelet-Rich Plasma), and Injury Rehabilitation
- Lack of controlled studies on the effectiveness of BPC-157 and PRP injections for faster recovery
- Stem cells not FDA approved in the US but used in other countries
- Importance of clinical trials and data when considering peptides, stem cells, and PRP
- Uncertainty regarding the effectiveness of stem cells, BPC-157, and PRP
- Opportunity cost associated with these treatments, including financial and personal investments
- Personal experience with ineffective alternative options to surgery, such as stem cell infusion
- Importance of designing trials to accurately identify the patient population that would benefit from stem cell treatments
- Questioning the motivation and incentive for legitimizing these procedures
- FDA-approved peptides showing potential in adjusting anxiety and aggression, but not widely available for psychiatric illnesses
- Emphasis on not relying solely on these treatments as a crutch, but putting in the hard work of rehabilitation
- Importance of exercise, nutrition, and hormones for vitality and longevity
- Misconception that simply injecting stem cells can replace dedicated rehabilitation exercises
- Personal experience with BPC-157 showing no noticeable effects
Metabolomics & Exercise
Metabolomics & Exercise Summary:
Metabolomics is the study of metabolites in the body, focusing on understanding their profile in different physiological states. Exercise has a distinct metabolomic profile compared to a non-exercise state, suggesting its potential benefits.
Key points:
- Metabolomics explores the effects of exercise on the body.
- Small molecules discovered through metabolomics could replicate some protective benefits of exercise.
- Combining these molecules with exercise could have significant health benefits and potentially treat diseases like diabetes.
- Metabolomics is an untapped frontier with promising potential for the future.
- GLP-1 and pharmacology are currently being discussed in relation to exercise and its effects.
GLP-1 & Weight Loss
GLP-1, a potential obesity drug, is considered safer and more effective than previous drugs like fen-phen. However, GLP-1 agonists can cause muscle loss along with fat loss. Semaglutide, a GLP-1 agonist, has shown promise in reducing weight but has side effects like nausea. It works in the hypothalamus and improves insulin sensitivity. Newer versions of GLP-1 agonists with longer-lasting effects are being developed. Concerns about long-term use and resistance exist, and cheating the drug's effects is possible. GLP-1 should complement behavioral changes for better health and longevity. Dr. Peter Attia discusses the complexities and potential of GLP-1 as a therapeutic target for obesity.
Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter, Huberman Lab Clips
The most profound aspect of the topic is the various ways to support the Huberman Lab Podcast, all of which are zero cost and offer valuable health-related information.
Key points:
- Subscribing to the Huberman Lab Podcast's YouTube channel
- Leaving reviews on Spotify and Apple
- Checking out their sponsors and partners, such as Momentous supplements and Athletic Greens
- Following them on social media, including Twitter and Instagram
- Signing up for their Neural Network monthly newsletter
The video also discusses the Huberman Lab Podcast's clips channel on YouTube, which provides brief clips on various health topics. This channel is particularly useful for catching up on missed episodes or exploring the podcast's back catalog. The video concludes with gratitude for the viewers' interest in science.